<p><span style="font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif; font-size: 14px;">Schwann cells (SCs) are myelinating cells of the PNS. Although SCs are known to express different channels and receptors on their surface, little is known about the activation and function of these proteins. Ionotropic glutamate receptors are thought to play an essential role during development of SC lineage and during peripheral nerve injury, so we sought to study their functional properties. We established a novel preparation of living peripheral nerve slices with preserved cellular architecture and used a patch-clamp technique to study AMPA-receptor (AMPAR)-mediated currents in SCs for the first time. We found that the majority of SCs in the nerves dissected from embryonic and neonatal mice of both sexes respond to the application of glutamate with inward current mediated by Ca</span><span style="-webkit-font-smoothing: antialiased; font-size: 0.75em; position: relative; bottom: 0.5em; margin: 0px; padding: 0px; border: 0px; outline: 0px; vertical-align: baseline; font-variant-numeric: inherit; font-stretch: inherit; line-height: inherit; font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif;">2+</span><span style="font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif; font-size: 14px;">-permeable AMPARs. Using stationary fluctuation analysis (SFA), we demonstrate that single-channel conductance of AMPARs in SCs is 8–11 pS, which is comparable to that in neurons.&nbsp;</span></p><p><img src="/pafciconlineprod/web/uploads/media/106.jpeg" data-href="/pafciconlineprod/web/uploads/media/106.jpeg" style="width: 447px; height: 334.5px;"><span style="font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif; font-size: 14px;"><br></span><br></p>